Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups
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منابع مشابه
Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups
BACKGROUND Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa. Lactase non-persistence is the most common phenotype in humans, except in northwestern Europe with its long history of pastoralism and milking. We had previously shown association of LCT -13910C>T polymorphism...
متن کاملLCT‐22018G>A single nucleotide polymorphism is a better predictor of adult‐type hypolactasia/lactase persistence in Japanese‐Brazilians than LCT‐13910C>T
Adult type hypolactasia, the genetically programmed down-regulation of lactase enzyme activity in the intestinal wall after weaning, is a common condition worldwide, except for in northwestern Europe, where the prevalence is less than 10%. Lactose intolerant individuals complain of abdominal cramps, bloating, distention, flatulence and diarrhea after milk or lactose-containing food ingestion. T...
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ABSTRACT Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the ...
متن کاملThe Frequency of the LCT*-13910C>T Polymorphism Associated with Lactase Persistence Diverges among Euro-Descendant Groups from Brazil
OBJECTIVE The aim of this study was to investigate the frequency of the LCT*-13910C>T polymorphism associated with a high expression of lactase in the small intestine during adulthood, and to infer the lactase persistence and adult-type hypolactasia phenotypes among Euro-Brazilians and Mennonites from South Brazil. MATERIALS AND METHODS A sequence-specific PCR method to genotype the LCT*-1391...
متن کاملfrequency of c3435 mdr1 and a6896g cyp3a5 single nucleotide polymorphism in an iranian population and comparison with other ethnic groups
abstract background: it is well recognized that different patients respond in different ways to medications. the inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. the recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the h...
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ژورنال
عنوان ژورنال: Nutrition Journal
سال: 2009
ISSN: 1475-2891
DOI: 10.1186/1475-2891-8-46